Sanghee Yun

Sep 25, 2024 | onlinelibrary.wiley.com | Sanghee Yun |Frederico C Kiffer |Grace L. Bancroft |Caterina S. Guzman

33-beam-GCR 33-beam galactic cosmic radiation 3-CSI 3-chamber social interaction AALAC Association for Assessment and Accreditation of Laboratory Animal Care Acq acquisition BLAF Brookhaven Laboratory Animal Facility BNL Brookhaven National Laboratory CDDO-EA 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid-ethylamide CNS central nervous system DCX doublecortin DCX+ doublecortin-immunoreactive EPM elevated plus maze Ext extinction GCR galactic cosmic radiation h hour(s) Hab habituation IACUC...

Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more

AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.

Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more

AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.

May 22, 2024 | biorxiv.org | Danielle Guez-Barber |Sofia Nicolayevsky |Kaya Johnson |Sanghee Yun

AbstractBackground: Rodent models for perinatal hypoxic ischemic (HI) encephalopathy have reported sex differences such as the same injury causing larger lesions in the brains of males compared to females. Microglia, the resident immune cells of the brain that have sex-dependent developmental trajectories and gene expression patterns, likely play a different role in females and males following HI.

Apr 15, 2024 | biorxiv.org | Sanghee Yun |Ivan Soler |Frederico C Kiffer |Catalina S Guzman

AbstractGalactic cosmic radiation (GCR) is an unavoidable risk to astronauts that may affect mission success. Male rodents exposed to 33-beam-GCR (33-GCR) show short-term cognitive deficits but reports on female rodents and long-term assessment is lacking. Here we asked: What are the longitudinal behavioral effects of 33-GCR on female mice? Also, can an antioxidant/anti-inflammatory compound mitigate the impact of 33-GCR?