Sofie Van Gassen

Jun 1, 2024 | biorxiv.org | Paulina Rybakowska |Sofie Van Gassen |Guillermo Barturen |Carlos Pérez Sánchez |Carlos Sanchez

AbstractBackground: Systemic autoimmune diseases (SADs) are characterized by internal heterogeneity, overlapping clinical symptoms, and shared molecular pathways. Therefore, they are difficult to diagnose and new tools allowing precise diagnosis are needed. Molecular-based reclassification studies enable to find patterns in a diagnosis-independent way. Objective: To evaluate the possibility of using high-content immunophenotyping for detecting patient subgroups in the context of precise treatment.

Mar 8, 2024 | nature.com | Sofie Van Gassen

AbstractMyelodysplastic neoplasms (MDS) encompass haematological malignancies, which are characterised by dysplasia, ineffective haematopoiesis and the risk of progression towards acute myeloid leukaemia (AML). Myelodysplastic neoplasms are notorious for their heterogeneity: clinical outcomes range from a near-normal life expectancy to leukaemic transformation or premature death due to cytopenia.

Feb 9, 2023 | nature.com | Sofie Van Gassen

To the EditorMyelodysplastic neoplasms (MDS) are age-associated hematopoietic neoplasms characterized by myeloid dysplasia and cytopenias. Patients with MDS have a diverse clinical course, ranging from indolent conditions to acute myeloid leukemia (AML) [1]. Sequencing of leukocytes from MDS patients revealed somatic mutations that correlated with their clinical outcome.