Somanath Jagannath

1 month ago | cell.com | Carlo Scialo |Weijia Zhong |Somanath Jagannath |Oscar G. Wilkins |Davide Caredio |Marian Hruska-Plochan | +8 more

Keywords TDP-43 low-complexity domain RNA-binding proteins aggregation seeding spreading loss of function cryptic splicing neurodegeneration ALS/FTD Introduction Despite apparent differences, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasingly recognized to have clinical, genetic, and pathological overlap.1 Transactive response DNA-binding protein of 43 kDa (TDP-43) is the major component of ubiquitinated cytoplasmic inclusions observed in both ALS and FTD...