Davide Caredio

1 month ago | cell.com | Carlo Scialo |Weijia Zhong |Somanath Jagannath |Oscar G. Wilkins |Davide Caredio |Marian Hruska-Plochan | +8 more

Keywords TDP-43 low-complexity domain RNA-binding proteins aggregation seeding spreading loss of function cryptic splicing neurodegeneration ALS/FTD Introduction Despite apparent differences, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasingly recognized to have clinical, genetic, and pathological overlap.1 Transactive response DNA-binding protein of 43 kDa (TDP-43) is the major component of ubiquitinated cytoplasmic inclusions observed in both ALS and FTD...

Sep 11, 2024 | journals.plos.org | Davide Caredio |Marusa Koderman |Karl Frontzek |Silvia Sorce |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Caredio D, Koderman M, Frontzek KJ, Sorce S, Nuvolone M, Bremer J, et al. (2024) Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle. PLoS Pathog 20(9): e1012552. https://doi.org/10.1371/journal.ppat.1012552Editor: Neil A.

May 6, 2024 | biorxiv.org | Davide Caredio |Marusa Koderman |Karl Frontzek |Silvia Sorce

AbstractIn prion diseases, aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally. Here we sequenced mRNA transcripts in skeletal muscle, spleen and blood of prion-inoculated mice at eight timepoints during disease progression. We detected gene-expression changes in all three organs, with skeletal muscle showing the most consistent alterations.

Nov 2, 2023 | biorxiv.org | Karl Frontzek |Silvia Sorce |Davide Caredio |Marusa Koderman

AbstractIn prion diseases, aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but can also be found in various extraneural tissues. This raises the question whether prion-specific pathologies arise also in these tissues. Here we sequenced mRNA transcripts in skeletal muscle, spleen and blood of prion-inoculated mice at eight timepoints during disease progression.