Sophie E Ayscough

Jan 27, 2025 | biorxiv.org | Sebastian Köhler |Sophie E Ayscough |Luke Ashley Clifton |Jörgen Ådén

AbstractThe Bcl-2 family of proteins control mitochondrial outer membrane (MOM) pore formation, crucial to cellular clearance via apoptosis. However, the molecular principles by which opposing family members inhibit, mediate or promote MOM perforation remain elusive. Here, we demonstrate that cell-protecting Bcl-2 directly sequesters cell-killing Bax into a protein-protein complex at the membrane interface preventing Bax forming apoptotic pores.