Sridevi Challa

Oct 14, 2023 | biorxiv.org | Sridevi Challa |Amy Gong |Charles Renshaw |Hyung Bum Kim

AbstractMono(ADP-ribosyl)ation (MARylation), a post-translational modification (PTM) of proteins, is emerging as a critical regulator of ribosome function and translation. Herein, we demonstrate that RACK1, a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and an integral component of the ribosome, is MARylated by the mono(ADP-ribosyl) transferase (MART) PARP14 in ovarian cancer cells.