Stacy M Horner

Dec 19, 2024 | science.org | Nandan S. Gokhale |Russell K Sam |Kim Y. Somfleth |Daphnee M Marciniak |Julian Smith |Emmanuelle Genoyer | +9 more

Supplementary MaterialsMDAR Reproducibility ChecklistReferences and notes1J. Rehwinkel, M. U. Gack, RIG-I-like receptors: Their regulation and roles in RNA sensing. Nat. Rev. Immunol. 20, 537–551 (2020). 2R. Savan, M. Gale Jr., Innate immunity and interferon in SARS-CoV-2 infection outcome. Immunity 56, 1443–1450 (2023). 3Y. J. Crow, J.-L. Casanova, Human life within a narrow range: The lethal ups and downs of type I interferons. Sci. Immunol. 9, eadm8185 (2024). 4H. Kato, O. Takeuchi, S. Sato, M. Yoneyama, M.

Jan 1, 2024 | nature.com | Matthew Thompson |Christopher L. Holley |Stacy M Horner

AbstractThe N6-methyladenosine (m6A) modification is found in thousands of cellular mRNAs and is a critical regulator of gene expression and cellular physiology. m6A dysregulation contributes to several human diseases, and the m6A methyltransferase machinery has emerged as a promising therapeutic target. However, current methods for studying m6A require RNA isolation and do not provide a real-time readout of mRNA methylation in living cells.

Nov 16, 2023 | cell.com | Matthew Thompson |Stacy M Horner

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