Stefan Holdenrieder

Mar 22, 2025 | respiratory-research.biomedcentral.com | De Vadder |Bartolomeo Bo |Neil Patel |Stefan Holdenrieder |Andreas Mueller |Florian Kipfmueller | +3 more

We performed a prospective single-center (University Hospital of Bonn) subgroup analysis of CDH newborns born between 2014 and 2022, who were initially enrolled in the “Biomarker forOutcomePredictionin Neonates withCongenital Diaphragmatic Hernia” (BIOPTIC) study (Clinical trial registration with German Clinical Trial Register (DKRS), trial registration number: DKRS00034329; Registration date: 24.05.2024).

Oct 25, 2024 | mdpi.com | Frank Klawonn |Georg Hoffmann |Stefan Holdenrieder |Inga Trulson

1. IntroductionReference intervals (RIs) are crucial for interpreting laboratory results in clinical practice. Defined as the central 95% range of a presumably healthy population’s values, RIs help determine whether a lab result should be considered “pathological” or not. Traditionally, these intervals are established using direct methods, which involve measuring analyte levels in a sufficiently large and well-characterized healthy reference group [1].