Stefania Kalogera

May 30, 2023 | mdpi.com | Mylène P. Jansen |Anne-Christine Bay-Jensen |Peder Frederiksen |Stefania Kalogera

1. IntroductionOsteoarthritis (OA) is the most common form of arthritis and is characterized by chronic pain and disability [1]. The main hallmarks of OA include cartilage degradation, osteophyte formation, subchondral bone remodeling, and inflammation of the synovium. Joint pain is the most common clinical OA manifestation; however, the association between structural changes and pain is still not completely understood.