Stefano Annunziato

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Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition

Oct 9, 2024 | biorxiv.org | Georg Petzold |Pablo Gainza |Stefano Annunziato |Ilaria Lamberto

AbstractThe CRL4CRBN ubiquitin ligase is leveraged by molecular glue degraders, small molecules that reprogram ligase specificity to induce degradation of clinically relevant neosubstrate proteins. Known CRBN neosubstrates share a generalizable β-hairpin G-loop recognition motif, yet systematic exploration of the CRBN target landscape is still pending.

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