Steffen Durinck

Aug 12, 2023 | biorxiv.org | Ben Korin |Shimrit Avraham |Andrew McKay |Steffen Durinck

AbstractMost causes of chronic kidney disease begin with injury to the glomerulus and involve progressive loss of kidney function. The glomerulus is a capillary bed where blood filtration to produce urine in the kidney occurs. During aging, there is progressive loss of glomeruli and filtration capacity of the kidney because podocytes, the glomerular epithelial cell, are lost with aging and after injury. Podocytes cannot divide and therefore cannot be replaced.