Shimrit Avraham

Nov 6, 2024 | nature.com | Mayra Cruz Tleugabulova |Sandra P. Melo |Meizi Liu |Antonie Lechner |Basak Corak |Jonathan J. Hodgins | +5 more

AbstractMacrophages are pleiotropic and diverse cells that populate all tissues of the body. Besides tissue-specific resident macrophages such as alveolar macrophages, Kupffer cells, and microglia, multiple organs harbor at least two subtypes of other resident macrophages at steady state. During certain circumstances, like tissue insult, additional subtypes of macrophages are recruited to the tissue from the monocyte pool.

Oct 18, 2023 | biorxiv.org | Shimrit Avraham |Ben Korin |Jerry Lo |Mayra Cruz Tleugabulova

AbstractRecent evidence suggests that the interaction between the tumor microenvironment (TME) and systemic host environment can alter the host immune system to promote anti-tumor activity. Here, we investigated whether glomerular immune injury affects cancer progression. We used nephrotoxic serum nephritis (NTN), a model for glomerular immune injury, and followed it by cancer cell implantation. NTS-injected mice developed smaller primary tumors compared with controls.

Aug 12, 2023 | biorxiv.org | Ben Korin |Shimrit Avraham |Andrew McKay |Steffen Durinck

AbstractMost causes of chronic kidney disease begin with injury to the glomerulus and involve progressive loss of kidney function. The glomerulus is a capillary bed where blood filtration to produce urine in the kidney occurs. During aging, there is progressive loss of glomeruli and filtration capacity of the kidney because podocytes, the glomerular epithelial cell, are lost with aging and after injury. Podocytes cannot divide and therefore cannot be replaced.

May 13, 2023 | biorxiv.org | Ben Korin |Shimrit Avraham |Reuben Moncada |Terence Ho

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.