Stephanie Spada

May 2, 2024 | biorxiv.org | Stephanie Spada |Kevin Rose |Paola Sette |Sarah O'Connor

AbstractThe Endosomal Sorting Complex Required for Transport (ESCRT) is an evolutionarily conserved machinery that performs reverse-topology membrane scission in cells universally required from cytokinesis to budding of enveloped viruses. Upstream acting ESCRT-I and ALIX control these events and link recruitment of viral and cellular partners to late-acting ESCRT-III CHMP4 through incompletely understood mechanisms.