Kevin Rose

2 weeks ago | biorxiv.org | Eric Herrmann |Kevin Rose |James Hurley

AbstractIn a recent publication, Lange et al.1 proposed an 11-spoked wheel model for the mitochondrial prohibitin complex consisting of six PHB1 and five PHB2 subunits built into low resolution density obtained from 11-fold symmetry averaging. The proposed unequal stoichiometry is inherently incompatible with symmetry. The building of an asymmetric molecular model into density obtained by 11-fold symmetry averaging is inherently self-contradictory.

May 2, 2024 | biorxiv.org | Stephanie Spada |Kevin Rose |Paola Sette |Sarah O'Connor

AbstractThe Endosomal Sorting Complex Required for Transport (ESCRT) is an evolutionarily conserved machinery that performs reverse-topology membrane scission in cells universally required from cytokinesis to budding of enveloped viruses. Upstream acting ESCRT-I and ALIX control these events and link recruitment of viral and cellular partners to late-acting ESCRT-III CHMP4 through incompletely understood mechanisms.