Stephen Baker

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Articles

Exploiting human immune repertoire transgenic mice for protective monoclonal antibodies against antimicrobial resistant Acinetobacter baumannii - Nature Communications

Sep 12, 2024 | nature.com | Stephen Baker |Sophie L. Higham |Josefin Bartholdson Scott |Leah Roberts |Simon Watson |Mili Estee Torok | +2 more

AbstractThe use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify monoclonal antibodies that may prevent infection caused by carbapenem resistant Acinetobacter baumannii.
Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance - Nature Communications

Jul 19, 2024 | nature.com | Kaiyuan Min |Kangkang Liu |Yarong Wu |Yujun Cui |Haiyan Yang |Stephen Baker | +3 more

AbstractSalmonella enterica serovar Typhimurium (S. Typhimurium) is a major cause of salmonellosis, and the emergence of multidrug-resistant pathovariants has become a growing concern. Here, we investigate a distinct rough colony variant exhibiting a strong biofilm-forming ability isolated in China. Whole-genome sequencing on 2,212 Chinese isolates and 1,739 publicly available genomes reveals the population structure and evolutionary history of the rough colony variants.

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