Stephen Burgess

Oct 14, 2024 | ias.org.uk | Stephen Burgess

Is drinking a moderate amount of alcohol bad for you? Answering questions about potential causal effects in humans is difficult. If you want to know what factors affect the lifespan of a lightbulb, your task is simple: get a few hundred lightbulbs, and start experimenting. Lightbulbs are cheap, available, and (for the large part) homogeneous – they all behave the same way. Humans are none of those things.

Nov 8, 2023 | jamanetwork.com | Michael Levin |Stephen Burgess

Mendelian Randomization and Cardiovascular Disease—Enabling Expert Readership A robust preclinical pipeline of evidence is the ideal prerequisite needed for responsible design and cost-sensitive execution of sometimes multimillion dollar cardiovascular-event–driven randomized clinical trials.

Nov 8, 2023 | jamanetwork.com | Michael Levin |Stephen Burgess

Abstract Importance  Mendelian randomization (MR) is a statistical approach that has become increasingly popular in the field of cardiovascular disease research. It offers a way to infer potentially causal relationships between risk factors and outcomes using observational data, which is particularly important in cases where randomized clinical trials are not feasible or ethical.

Aug 22, 2023 | mdpi.com | Qi Feng |Andrew Grant |Qian Yang |Stephen Burgess

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Feb 2, 2023 | cell.com | Stephen Burgess |Amy Mason |Andrew Grant |Eric A.W. Slob

Limitations and future directionsThe limitations of Mendelian randomization have been widely discussed since the conception of the approach., We focus here on limitations of Mendelian randomization for testing a causal hypothesis and those particularly relevant to drug discovery and development; several other limitations have already been discussed in the relevant sections.