Steven F. Gameiro

Nov 16, 2023 | frontiersin.org | Takumi Kumai |Sankar Jagadeeshan |Steven F. Gameiro |Erik Hooijberg

IntroductionTonsillar cancer, i.e., squamous cell cancer localized to the palatine tonsils of the oropharynx, is now mainly caused by high-risk human papillomaviruses (HPV). Indeed, HPV+ tonsillar cancer currently accounts for 70-80% of cases in Western Europe and the United States (1). It is more treatment sensitive and has a better prognosis than the HPV- subset, which is associated with smoking of tobacco and alcohol abuse.