Takumi Kumai

Jul 1, 2024 | onlinelibrary.wiley.com | Risa Wakisaka |Takumi Kumai |Hiroki Komatsuda |Hidekiyo Yamaki

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description coa14195-sup-0001-supinfo.pptxPowerPoint 2007 presentation , 4.9 MB Table S1. Summary of cut-off values according to ROC curve. Table S2. Summary of correlations between PET parameters and haematological parameters. Table S3. Summary of median OS and PFS of the cancer from each primary site. Figure S1. Overall survival and progression-free survival curve. Figure S2.

Mar 20, 2024 | cureus.com | Takahiro Inoue |Takumi Kumai |Miki Takahara |Tomoki Yoshizaki

SpecialtyPlease chooseI'm not a medical professional. Allergy and ImmunologyAnatomyAnesthesiologyCardiac/Thoracic/Vascular SurgeryCardiologyCritical CareDentistryDermatologyDiabetes and EndocrinologyEmergency MedicineEpidemiology and Public HealthFamily MedicineForensic MedicineGastroenterologyGeneral PracticeGeneticsGeriatricsHealth PolicyHematologyHIV/AIDSHospital-based MedicineI'm not a medical professional.

Nov 20, 2023 | frontiersin.org | Takumi Kumai |Marc Oliva |Hirofumi Shibata

IntroductionThe treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) was significantly advanced with introduction of the anti-EGFR antibody cetuximab (Cmab) in 2005 (1), and further improved with the advent of immune checkpoint inhibitors (ICIs) (2, 3). Among these, the anti-programmed cell death protein 1 (PD-1) antibodies pembrolizumab and nivolumab have become the standard systemic therapy for R/M SCCHN.

Nov 16, 2023 | frontiersin.org | Takumi Kumai |Sankar Jagadeeshan |Steven F. Gameiro |Erik Hooijberg

IntroductionTonsillar cancer, i.e., squamous cell cancer localized to the palatine tonsils of the oropharynx, is now mainly caused by high-risk human papillomaviruses (HPV). Indeed, HPV+ tonsillar cancer currently accounts for 70-80% of cases in Western Europe and the United States (1). It is more treatment sensitive and has a better prognosis than the HPV- subset, which is associated with smoking of tobacco and alcohol abuse.

Sep 15, 2023 | frontiersin.org | Tomoko Yamazaki |Quan Chen |Takumi Kumai |Tetsuro Wakasugi

1 IntroductionSurgery and radiation therapy are definitive treatments for local squamous cell carcinoma of the head and neck (SCCHN), and concurrent platinum-based chemoradiotherapy has been used as the standard of care in both definitive and adjuvant settings (1–5).