Steven Kottaras

May 1, 2023 | mdpi.com | Giti Borzooeian |Rozalia Kouvelioti |Madison Smartt Bell |Steven Kottaras

1. IntroductionExercise has a significant impact on bones, and the metabolism of bone cells adjusts quickly to training [1]. The bone response to exercise is based on mechanical stimulation, as well as the integration of biochemical signals generated during and after exercise [2]. Recent evidence indicates that exercise leads to increased secretion of the myokine irisin, which plays a significant role in bone homeostasis and metabolic regulation [3].