Stevens Robertin

Aug 5, 2024 | cell.com | Dominik Brokatzky |Keppel Street |Margarida Gomes |Stevens Robertin

Highlights•Septins promote macrophage pyroptosis induced by LPS/nigericin and Shigella infection•Septins assemble as filaments at the plasma membrane and promote cleavage of gasdermin D•Septins regulate mitochondrial dynamics and the expression of cell membrane protein NINJ1•Septin-mediated pyroptosis is required for host defense in Shigella infection of zebrafishSummaryThe septin cytoskeleton is primarily known for roles in cell division and host defense against bacterial infection.