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1 month ago | 
channelnewsasia.com | Stuart Smith |William Denselow |Nick Harper
KYIV: Another year of war has passed. Residents of Ukraine’s capital Kyiv have come to expect daily air-raid sirens and explosions to break the silence of nightly curfews. Soldiers continue to shiver in sub-zero temperatures along a largely frozen frontline. Thousands of Ukrainians continue to die trying to stall incremental Russian progress. But the war has also evolved. For the first time since Russia’s full-scale invasion three years ago, there is serious talk of negotiations to an end.
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2 months ago | 
channelnewsasia.com | Stuart Smith |William Denselow
The US special envoy to Ukraine is in Kyiv. Keith Kellogg said that he is there to hear the concerns of a country now almost three years into a full-scale Russian invasion. Mr Kellogg will meet the Ukrainian president and the Commander in Chief of Ukraine's Armed Forces, and share his findings with US President Donald Trump. Kyiv has repeatedly stressed it needs Washington to deliver security guarantees, sufficient to deter Moscow from launching a new invasion after a peace deal is reached.
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Dec 3, 2024 | 
channelnewsasia.com | Stuart Smith
LONDON: Singapore’s extradition request for fugitive lawyer Charles Yeo is due to be heard in May 2025. He appeared at Westminster Magistrate’s Court in London on Tuesday (Dec 3) as part of the initial hearing. Yeo, 34, spoke from behind a screen only to confirm his name and date of birth. The UK's Crown Prosecution Service told CNA that he is wanted by Singapore authorities over claims of the abetment of cheating.
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Nov 25, 2024 | 
beat.com.au | Stuart Smith
A mix of heavy bands are uniting for a great cause to raise money for survivors of abuse. Proceeds from this show will be donated to GIVIT. Tickets $20+BF/$25 on the Door (if available).
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Nov 6, 2024 | 
scrippsnews.com | Stuart Smith |Alex Arger
Statements of congratulations came in from all over the world Wednesday, particularly from countries that consider themselves U.S. allies or those that would like to improve their ties with the United States under President-elect Donald Trump.
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Nov 6, 2024 | 
wtvr.com | Stuart Smith |Alex Arger
Statements of congratulations came in from all over the world Wednesday, particularly from countries that consider themselves U.S. allies or those that would like to improve their ties with the United States under President-elect Donald Trump.
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Nov 5, 2024 | 
newschannel5.com | Stuart Smith |Alex Arger |Elina Tarkazikis |Justin Boggs
Election Day is TODAY: Here's everything you need to know!The November general election is around the corner and we've got everything you need to know before you head to the polls!
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Oct 22, 2024 | 
nature.com | Riccardo Serra |Stuart Smith |Jonathan Rowlinson |Noah Leviton Gorelick |Gareth J. Veal |Philip A Berry | +10 more
There is increased pan-cancer specific interest in repurposing the poly adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly diagnosed or recurrent isocitrate dehydrogenase wild type glioblastoma. We explore whether intra-cavity delivery of olaparib confers a survival benefit in a pre-clinical high-grade glioma model. Primary tumor RNA sequencing data was used to determine PARP-1 as a target in the glioblastoma infiltrative margin. We assessed radiosensitization conferred by olaparib alone and concomitant to genotoxic insults in vitro using clonal growth assays, cell cycle analysis and immunocytochemistry, and in vivo upon post-surgical delivery from a temperature-sensitive polymeric paste. RNA-sequencing confirmed PARP-1 as a viable therapy target in glioblastoma infiltrative disease. Acute exposure of glioma cells to olaparib impaired proliferation and induced late-stage apoptosis associated with DNA damage in vitro, potentiated by radiation. Using high-grade glioma orthotopic allografts, a long-term overall survival benefit was observed upon interstitial olaparib delivery concomitant with radiotherapy, compared to systemic olaparib and standard glioblastoma treatment. Combined delivery of olaparib with either temozolomide or etoposide increased long-term survival, suggestive of olaparib functioning as DNA damage sensitizer. Collectively, our data support a rationale for localized olaparib delivery concomitant with the current clinical regimen for malignant glioma treatment.
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Oct 15, 2024 | 
channelnewsasia.com | Stuart Smith |Louisa Tang
World Chinese exporters are suspected of flooding the market with cheap and blended honey products which could harm people’s health. New: You can now listen to articles. BEDFORDSHIRE, United Kingdom: Honey is a pantry staple in many homes around the world, with a global market size of US$9 billion and growing.
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Oct 8, 2024 | 
channelnewsasia.com | Stuart Smith |Calvin Yang
LONDON: Auction prices for top-tier artworks are falling. Major global auction houses had a significant combined year-on-year decline in sales of 17.5 per cent last year, with the downturn attributed to external economic and geopolitical pressures, according to art market research firm ArtTactic. At the top end of the auction house industry, it is the big sales that matter. Transactions above £1 million (US$1.3 million) only account for around 5 per cent of lots sold.
