Sudha Rajderkar

Mar 5, 2024 | nature.com | Sudha Rajderkar |Maria Amaral |Laura Cook |Fabrice Darbellay |Cailyn H. Spurrell |Marco Osterwalder | +9 more

AbstractThe genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development. However, a lack of accurate maps of the genomic locations and cell type-resolved activities of craniofacial enhancers prevents their systematic exploration in human genetics studies.