Marco Osterwalder

Mar 5, 2024 | nature.com | Sudha Rajderkar |Maria Amaral |Laura Cook |Fabrice Darbellay |Cailyn H. Spurrell |Marco Osterwalder | +9 more

AbstractThe genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development. However, a lack of accurate maps of the genomic locations and cell type-resolved activities of craniofacial enhancers prevents their systematic exploration in human genetics studies.

Oct 18, 2023 | nature.com | Brandon J. Mannion |Dunja Knapp |Fabian Lim |Anna Czarkwiani |Viviana Hermosilla Aguayo |Licia Selleri | +6 more

AbstractThe cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is controlled in the mammalian notochord has remained elusive. Here, we identify the complement of notochord-specific enhancers in the mammalian Brachyury/T/TBXT gene.

Jul 6, 2023 | nature.com | Iros Barozzi |Marco Osterwalder |Susan Mackem |Terence D. Capellini |Diane E. Dickel |Nicoletta Bobola | +5 more

AbstractA lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the elusive mechanisms whereby PBX TALE homeoproteins, viewed primarily as HOX cofactors, attain context-specific developmental roles despite ubiquitous presence in the embryo.