Sunil Raikar

1 month ago | nature.com | Hope Mumme |Chenbin Huang |Denis J. Ohlstrom |Sunil Raikar |Deborah DeRyckere |Christopher Porter | +2 more

AbstractSingle-cell transcriptome profiling enables unparalleled characterization of the heterogeneous microenvironment of pediatric leukemias. To facilitate comparative analyses and generate pediatric leukemia signatures, we collect, process, and annotate single-cell data comprising over 540,000 cells from 159 different pediatric acute leukemia (myeloid, lymphoid, mixed phenotype lineages) and healthy bone marrow (BM) samples, profiled in our lab and curated from publicly available studies.

Sep 25, 2024 | nature.com | Justus M. Huelse |Swati Bhasin |Sunil Raikar |Stephen Frye |Deborah DeRyckere |Juhye Yim

AbstractTAM-family tyrosine kinases (TYRO3, AXL and MERTK) are potential cancer therapeutic targets. In previous studies MERTK inhibition in the immune microenvironment was therapeutically effective in a B-cell acute leukemia (B-ALL) model. Here, we probed anti-leukemia immune mechanisms and evaluated roles for TYRO3 and AXL in the leukemia microenvironment.