Susan Bender

Jul 26, 2024 | digitalcommons.library.tmc.edu | Megan Palmisano |Jeaneen Kulp |Susan Bender |Darko Stefanovski

BACKGROUND: Eight-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative damage evaluated in human neurodegenerative disease, has potential to correlate with postmortem diagnosis of neuroaxonal dystrophy/degenerative myeloencephalopathy (NAD/DM) in horses. HYPOTHESIS: We hypothesized that 8-OHdG will be higher in CSF and serum from NAD/DM horses compared with horses with other neurologic diseases (CVSM, EPM) and a control group of neurologically normal horses.

Jan 11, 2024 | onlinelibrary.wiley.com | Megan Palmisano |Susan Bender |Darko Stefanovski |Jeaneen Kulp

3-NT 3-nitrotyrosine 4HNE 4-hydroxynonenal 8-OHdG 8-hydroxy-2′-deoxyguanosine CNS central nervous system CSF cerebrospinal fluid DM degenerative myeloencephalopathy NAD neuroaxonal dystrophy F2 isoP F2-isoprostane PBS phosphate-buffered saline ROS reactive oxygen species 1 INTRODUCTION The neurodegenerative disease termed neuroaxonal dystrophy (NAD)/degenerative myeloencephalopathy (DM) has become increasingly recognized as a cause of neurologic disease in horses. Diagnosis is based on...

Dec 14, 2023 | onlinelibrary.wiley.com | Susan Bender |Amy Johnson

EDM equine degenerative myeloencephalopathy eNAD equine neuroaxonal dystrophy CVC cervical vertebral column CAPJ cervical articular process joint EPM equine protozoal myeloencephalitis CBCT cone beam computed tomography 1 INTRODUCTION Degenerative myeloencephalopathy (EDM) and neuroaxonal dystrophy (eNAD) in horses has been reported in the veterinary literature for >40 years.