Duygu Tosun

Nov 6, 2024 | nature.com | Duygu Tosun |Meryl A. Butters |Andrew J. Saykin |Arthur W. Toga |Clifford R. Jack

AbstractThis study was conducted to clarify patterns of cortico-limbic volume abnormalities in late life depression (LLD) relative to non-depressed (ND) adults matched for amyloid β (Aβ) deposition and to evaluate the relationship of volume abnormalities with cognitive performance. Participants included 116 LLD and 226 ND. Classification accuracy of LLD status was estimated using area under the receiver operator characteristic curve.

Oct 4, 2024 | nature.com | Junhao Wen |Ilya M. Nasrallah |Guray Erus |Jingxuan Bao |Andrew J. Saykin |Timothy J. Hohman | +11 more

AbstractAlzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain atrophy in symptomatic mild cognitive impairment (MCI) and AD patients: the “diffuse-AD” (R1) dimension shows widespread brain atrophy, and the “MTL-AD” (R2) dimension displays focal medial temporal lobe (MTL) atrophy.

Aug 15, 2024 | nature.com | Zhijian Yang |Junhao Wen |Guray Erus |Elizabeth Mamourian |Katharina Wittfeld |Duygu Tosun | +17 more

AbstractBrain aging process is influenced by various lifestyle, environmental and genetic factors, as well as by age-related and often coexisting pathologies. Magnetic resonance imaging and artificial intelligence methods have been instrumental in understanding neuroanatomical changes that occur during aging.

Aug 10, 2024 | nature.com | Conor Owens-Walton |Tim Anderson |Michiel F. Dirkx |Hamied Haroon |Max A. Laansma |Tracy Melzer | +12 more

AbstractThe progression of Parkinson’s disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due to the use of heterogeneous methods in small studies. Here we performed a large diffusion MRI study in PD, integrating data from 17 cohorts worldwide, to identify stage-specific profiles of white matter differences.

Aug 10, 2024 | nature.com | Conor Owens-Walton |Tim Anderson |Michiel F. Dirkx |Hamied Haroon |Max A. Laansma |Tracy Melzer | +12 more

AbstractThe progression of Parkinson’s disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due to the use of heterogeneous methods in small studies. Here we performed a large diffusion MRI study in PD, integrating data from 17 cohorts worldwide, to identify stage-specific profiles of white matter differences.