Sushrut S. Waikar

Apr 3, 2024 | nature.com | Paola Fioretto |Frederik Persson |Sylvia E. Rosas |Peter Rossing |Jennifer Schaub |Katherine R. Tuttle | +1 more

AbstractDiabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear causes of kidney injury, occurs in approximately 20–40% of patients with diabetes mellitus. As the global prevalence of diabetes has increased, DKD has become highly prevalent and a leading cause of kidney failure, accelerated cardiovascular disease, premature mortality and global health care expenditure.

Jul 19, 2023 | nature.com | Seth Winfree |Qiwen Hu |Ricardo Melo Ferreira |Daria Barwinska |fei chen |Sushrut S. Waikar | +12 more

Statistics and reproducibilityFor 3D imaging and immunofluorescence staining experiments, each staining was repeated on at least two separate individuals or separate regions. For immunofluorescence validation studies, commercially available antibodies were used; 13 out of the 15 tissue samples were also analysed using snCv3 or scCv3. For ISH, 6 tissue samples (4 biopsies and 2 nephrectomies) were analysed.