Sydney S. Cash

Aug 13, 2024 | nature.com | Rina Zelmann |Peter N. Hadar |R. Mark Richardson |Ziv M. Williams |Sydney S. Cash |Corey Keller

AbstractTheta-burst stimulation (TBS), a patterned brain stimulation technique that mimics rhythmic bursts of 3–8 Hz endogenous brain rhythms, has emerged as a promising therapeutic approach for treating a wide range of brain disorders, though the neural mechanism of TBS action remains poorly understood. We investigated the neural effects of TBS using intracranial EEG (iEEG) in 10 pre-surgical epilepsy participants undergoing intracranial monitoring.

Jan 17, 2024 | nature.com | Angelique C. Paulk |Yun Goo Ro |Karen Tonsfeldt |Samantha Russman |R. Mark Richardson |Ziv M. Williams | +2 more

AbstractOver the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons.

Jun 14, 2023 | nature.com | Sydney S. Cash

ParticipantsParticipants were recruited as part of an ongoing, multi-site collaborative project between 2003 and 2016 (Beth Israel Deaconess Medical Center, Brigham and Women’s Hospital, Children’s Hospital and Massachusetts General Hospital in Boston, and New York University Medical Center, New York and Epilepsy Center of National Institute of Mental Health, Neurology and Neurosurgery (former names: Natl. Inst. of Psychiatry and Neurology, Natl. Inst. of Clinical Neurosciences, Budapest, Hungary).

Mar 29, 2023 | nature.com | Fangyun Tian |David Zhou |Gustavo A. Balanza |Angelique C. Paulk |Rina Zelmann |Noam Peled | +5 more

AbstractKetamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by its psychotropic side effects. Ketamine is thought to act via NMDA receptors and HCN1 channels to produce brain oscillations that are related to these effects.