Tahlia R. Meola

Aug 2, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractAtypical antipsychotics are crucial for the management of schizophrenia and bipolar disorder, yet they exhibit significant pharmacokinetic variability which leads to inconsistent therapeutic responses. This study investigates the hypothesis that gut microbiome composition critically influences the oral bioavailability of lurasidone, a poorly soluble weak base antipsychotic with pH-dependent solubility.

Aug 2, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractAtypical antipsychotics are crucial for the management of schizophrenia and bipolar disorder, yet they exhibit significant pharmacokinetic variability which leads to inconsistent therapeutic responses. This study investigates the hypothesis that gut microbiome composition critically influences the oral bioavailability of lurasidone, a poorly soluble weak base antipsychotic with pH-dependent solubility.

Jul 19, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractThis study investigates the impact of gut microbiome composition on the bioavailability and biodistribution of lurasidone hydrochloride, an atypical antipsychotic used in treating mental health conditions. The research aims to uncover the relationship between gut metabolome, specifically short-chain fatty acids (SCFAs), and lurasidone absorption through modulation of intestinal pH.

Feb 10, 2024 | bmjopen.bmj.com | Peter Brown |Julián Sáez Soriano |Tahlia R. Meola |Monique S Boord

Process evaluation to assess the feasibility of the pharmacist serviceA mixed methods evaluation, applying the RE-AIM evaluation framework30 will be performed to assess the feasibility of the pharmacist service. Descriptive statistics will be employed to report demographic characteristics and health information obtained from the Resident Care Assessment Record. To determine reach, the number and proportion of eligible residents who were willing to participate in the study will be calculated.