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Jan 21, 2025 | 
cardiab.biomedcentral.com | New Taipei |Taipei City
A critical age-dependent effect of SGLT2i on stroke risk in patients with DM and AF is revealed by our study. Our previous research has shown that SGLT2i generally protects against stroke in this population [4, 12]. However, our current analysis reveals a more complex picture: SGLT2i appears protective against stroke in patients under 75, neutral in those aged 75–90, and potentially detrimental in patients aged 90 and older.
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Jan 17, 2025 | 
molecularneurodegeneration.biomedcentral.com | Taipei City
CHI3L1 plays a central role in the pathology of a wide array of brain diseases, encompassing acute and chronic conditions. These include brain tumors [64], ischemic brain injury [22], brain trauma [65], and neurodegenerative disorders such as Alzheimer’s disease [2], Parkinson’s disease [66], amyotrophic lateral sclerosis [67] and Creutzfeldt-Jakob disease [29].
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Nov 24, 2024 | 
link.springer.com | Chang Gung College |Taipei City
AbstractOBI-858 is a brand-new botulinum Type A complex toxin with a specific molecular weight of 760 kDa intended for development for both aesthetic and therapeutic applications. This is a phase I, dose-escalation study to evaluate the safety and preliminary efficacy of OBI-858 in subjects with moderate to severe glabellar lines. Each subject received OBI-858 by intramuscular injections with an assigned dose (10 U, 20 U, and 30 U).
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Oct 11, 2024 | 
link.springer.com | Chang Gung |Taipei City
AbstractThis study aims to assess the impact of Traditional Chinese Medicine (TCM) on dementia patients, utilizing real-world data. Specifically, it seeks to evaluate how TCM influences clinical outcomes by examining changes in the Clinical Dementia Rating (CDR) and Mini-Mental State Examination (MMSE) scores, as well as its effect on medical expenses over a two-year period.
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Sep 24, 2024 | 
academic.oup.com | Taipei City
Sleep disturbances in later life are prevalent and can profoundly impact health and well-being. However, whether and how trajectories of sleep disturbances vary as people age by gender and across age cohorts remains unexplored. This study uses an integrated theoretical framework to understand gender-specific trajectories of sleep disturbances over time and how they vary by cohort.
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Sep 18, 2024 | 
jbiomedsci.biomedcentral.com | Taipei City
ReferencesAjoy R, Lo YC, Ho MH, Chen YY, Wang Y, Chen YH, Jing-Yuan C, Changou CA, Hsiung YC, Chen HM, Chang TH, Lee CY, Chiang YH, Chang WC, Hoffer B, Chou SY. CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation. Mol Psychiatry. 2021;26(11):6451–68. Article PubMed PubMed Central CAS Google Scholar Albert V, Subramanian A, Agrawal D, Bhoi SK, Pallavi P, Mukhopadhayay AK.
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Sep 16, 2024 | 
link.springer.com | Taipei City
AbstractTraumatic brain injury (TBI) causes axon tearing and synapse degradation, resulting in multiple neurological dysfunctions and exacerbation of early neurodegeneration; the repair of axonal and synaptic structures is critical for restoring neuronal function. C-C Motif Chemokine Ligand 5 (CCL5) shows many neuroprotective activities. A close-head weight-drop system was used to induce mild brain trauma in C57BL/6 (wild-type, WT) and CCL5 knockout (CCL5-KO) mice.
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Aug 8, 2024 | 
markets.businessinsider.com | Taipei City
Nekodex, a new on-chain crypto exchange from Perpetual Protocol, is now offering spot trading to users. Taipei City, Taiwan - August 8, 2024 — Nekodex, a new on-chain crypto exchange from Perpetual Protocol, is now offering spot trading to users, combining several recent Ethereum usability improvements that reduce the complexity associated with buying and selling cryptocurrencies across multiple blockchains.
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Aug 7, 2024 | 
news.marketersmedia.com | Taipei City
— Nekodex, a new on-chain crypto exchange from Perpetual Protocol, is now offering spot trading to users, combining several recent Ethereum usability improvements that reduce the complexity associated with buying and selling cryptocurrencies across multiple blockchains. Nekodex users can sign up in seconds and start trading without needing to understand or worry about installing wallets, managing gas fees, or bridging between chains.
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Aug 3, 2024 | 
money.mymotherlode.com | Taipei City
BYDFi Launches Limited-Time Maker Fee Event! — BYDFi, a top 10 global derivatives exchange, is thrilled to announce a special limited-time promotion for our valued users. During this exclusive event, spot maker orders will enjoy zero transaction fees, providing an exceptional trading experience and increased profitability for our traders.
