Tamas Faludi

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Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation | Nature Communications

Mar 22, 2024 | nature.com | Nick Huang |Akshay Patel |Frank Middleton |Brandon Wyman |Tamas Faludi |Daniel Krakko

AbstractActivation of the mechanistic target of rapamycin (mTOR) is a key metabolic checkpoint of pro-inflammatory T-cell development that contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), however, the underlying mechanisms remain poorly understood.

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