Tanveer Singh Batth

Oct 18, 2024 | biorxiv.org | Maico Lechner |Tanveer Singh Batth |Jesper V. Olsen |Cristina Hernandez-Rollan

AbstractThis study presents a comparative analysis of three LysC homologues from Achromobacter lyticus, Pseudomonas aeruginosa, and Lysobacter enzymogenes for mass spectrometry-based proteomics. Utilizing a protein aggregation capture (PAC) workflow with HeLa cell lysate, we assessed the enzymes' cleavage specificity, digestion efficiency, and performance across various experimental conditions.

Oct 15, 2024 | nature.com | Tanveer Singh Batth |Nadezhda T. Doncheva |Blanca Lopez Mendez |Blanca Méndez |Lars Jensen

AbstractProteins are the primary targets of almost all small molecule drugs. However, even the most selectively designed drugs can potentially target several unknown proteins. Identification of potential drug targets can facilitate design of new drugs and repurposing of existing ones. Current state-of-the-art proteomics methodologies enable screening of thousands of proteins against a limited number of drug molecules.