Theofanis Karayannis

Dec 1, 2024 | biorxiv.org | Asim Iqbal |Romesa Qaiser Khan |Theofanis Karayannis |Edith Gasser

AbstractMesoscale understanding of human brain development is crucial for understanding neurodevelopmental disorders. By applying AI techniques to analyze high-resolution, multi-modal brain imaging datasets across postnatal ages, researchers can study cortical development at the granular level. We introduce MortX, a benchmark dataset of the developing mouse cortex that captures multiple postnatal stages with annotations for distinct anatomical and functional subregions and layers.

Feb 14, 2024 | nature.com | Marian Hruska-Plochan |Vera I. Wiersma |Katharina M. Betz |Elena Tantardini |Florent Laferrière |Igor Delvendahl | +11 more

AbstractHuman cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies1, which involve human-specific mechanisms2,3,4,5 that cannot be directly studied in animal models.