Thilini Peramuna

May 26, 2024 | biorxiv.org | Monica Ness |Thilini Peramuna |Karen Wendt |Jennifer Collins

AbstractNatural product libraries are crucial to drug development, but large libraries drastically increase the time and cost during initial high throughput screens. Here, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce library size, with minimal bioactive loss. This method offers a broadly applicable strategy for accelerated drug discovery with cost reductions, which enable implementation in resource-limited settings.