Thomas C. Südhof

May 16, 2024 | cell.com | Bo Zhang |Thomas C. Südhof

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Oct 5, 2023 | biorxiv.org | Shuai Wang |Chelsea DeLeon |Bryan Roth |Thomas C. Südhof

AbstractHow synapses are assembled and specified in brain is incompletely understood. Latrophilin-3, a postsynaptic adhesion-GPCR, mediates Schaffer-collateral synapse formation in the hippocampus but the mechanisms involved remained unclear. Here we show that Latrophilin-3 organizes synapses by a convergent dual-pathway mechanism by which Latrophilin-3 simultaneously activates GαS/cAMP-signaling and recruits phase-separated postsynaptic protein scaffolds.

Oct 3, 2023 | biorxiv.org | Shuai Wang |Thomas C. Südhof |Wenfei Sun |Stephen R. Quake

AbstractThe assembly and specification of synapses in the brain is incompletely understood. Latrophilin-3, a postsynaptic adhesion-GPCR, mediates synapse formation in the hippocampus but the mechanisms involved remain unclear. Here we show that Latrophilin-3 organizes synapses by a novel dual-pathway mechanism: activation of GαS/cAMP-signaling and recruitment of phase-separated postsynaptic protein scaffolds.