Thomas Meyer

Nov 19, 2024 | science.org | Eyal Zoler |Matthew Knarr |Leslie K. Ferrarelli |Thomas Meyer

Editor’s summaryType I interferons (IFNs) stimulate antiviral or antiproliferative signaling in a cell type–dependent manner. The Janus kinases TYK2 and JAK1 are recruited to the IFN receptor subunits IFNAR1 and IFNAR2, respectively, cross-phosphorylating each other and STAT proteins to transduce IFN signals. However, in experiments with synthetic IFNARs and JAK-deficient cell lines, Zoler et al.