Thomas Thumberger

2 months ago | nature.com | Jakob Gierten |Tomas Fitzgerald |Thomas Thumberger |Rashi Aggrwwal |Adrien Leger |Kiyoshi Naruse | +2 more

AbstractThe polygenic contribution to heart development and function along the health-disease continuum remains unresolved. To gain insight into the genetic basis of quantitative cardiac phenotypes, we utilize highly inbred Japanese rice fish models, Oryzias latipes, and Oryzias sakaizumii. Employing automated quantification of embryonic heart rates as core metric, we profiled phenotype variability across five inbred strains.