Tomas Fitzgerald

2 months ago | nature.com | Jakob Gierten |Tomas Fitzgerald |Thomas Thumberger |Rashi Aggrwwal |Adrien Leger |Kiyoshi Naruse | +2 more

AbstractThe polygenic contribution to heart development and function along the health-disease continuum remains unresolved. To gain insight into the genetic basis of quantitative cardiac phenotypes, we utilize highly inbred Japanese rice fish models, Oryzias latipes, and Oryzias sakaizumii. Employing automated quantification of embryonic heart rates as core metric, we profiled phenotype variability across five inbred strains.

Jul 23, 2024 | biorxiv.org | Marcio Luis Ferreira |Márcio Ferreira |Sebastian Stricker |Tomas Fitzgerald |Jack Monahan

AbstractHigh resolution imaging of model organisms allows the quantification of important physiological measurements. In the case of fish with transparent embryos, these videos can visualise key physiological processes, such as heartbeat. High throughput systems can provide enough measurements for the robust investigation of developmental processes as well as the impact of system perturbations on physiological state.