Tianjian Laboratory

Jan 9, 2025 | onlinelibrary.wiley.com | Tianjian Laboratory |Fang Li |Dongdong Jian |Chenqiu Wang

1 Introduction The survival rate of cancer patients has significantly improved with the use of various chemotherapeutic drugs. However, the cardiotoxic adverse reactions associated with the use of chemotherapeutic drugs have become increasingly apparent. In addition to limiting the effectiveness of cancer treatment, these adverse reactions also severely affect the quality of life of cancer patients [1].

Nov 15, 2024 | aacrjournals.org | Tianjian Laboratory

Resistance to paclitaxel poses a major obstacle in esophageal squamous cell carcinoma (ESCC) treatment. A better understanding of the mechanisms underlying paclitaxel resistance could help identify prognostic biomarkers and improved therapeutic strategies. In this study, we established a patient-derived xenograft model of acquired paclitaxel resistance and used RNA sequencing to identify galectin-1, encoded by LGALS1, as a key mediator of resistance.

Nov 10, 2024 | bmcpsychiatry.biomedcentral.com | Tianjian Laboratory

The survey was conducted on clinical cases from March 2023 to October 2023 using paper questionnaire in the Department of Child Developmental Behavior, the Third Affiliated Hospital of Zhengzhou University. It was administered individually and took approximately 20 min to complete. All participating children’s parents were informed of the purpose and guidance of the survey, and that the research was entirely anonymous and voluntary.

Oct 25, 2024 | cell.com | Tianjian Laboratory

Keywordsfatty acidsfatty acid uptakecontext-specific regulationCD36protein palmitoylationGet full text accessLog in, subscribe or purchase for full access. References1. Berland, C. ... Dietary lipids as regulators of reward processes: multimodal integration mattersTrends Endocrinol. Metab. 2021; 32:693-7052. Chen, Y. ... Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male miceNat. Commun. 2023; 14:15213. Wang, J. ...

Aug 28, 2024 | cell.com | Bo Huang |Yi Zhang |Tianjian Laboratory

KeywordsCD8+ T cellPLPP1ferroptosislipid peroxidationPD-1 signalinganti-PD-1 therapyunsaturated fatty acidphospholipid metabolismantitumor immunitytumor microenvironmentGet full text accessLog in, subscribe or purchase for full access. References1. Lim, S.A. ∙ Su, W. ∙ Chapman, N.M. ... Lipid metabolism in T cell signaling and functionNat. Chem. Biol. 2022; 18:470-4812. Wang, R. ∙ Liu, Z. ∙ Fan, Z. ... Lipid metabolism reprogramming of CD8+ T cell and therapeutic implications in cancerCancer Lett.