Tik Muk

Oct 27, 2023 | onlinelibrary.wiley.com | Jing Yi Sun |Jingren Zhong |Tik Muk |Halise Gül Akıllıoğlu

1 Introduction Relative to term infants, preterm infants are born with immature organs and altered immune functions, making them vulnerable to neonatal infections and inflammation.[1, 2] Postnatal inflammation and infections have now become the leading causes of neonatal death and morbidity in children, and such effects may induce detrimental effects across multiple organs (e.g., lung, gut, kidney, and brain).[3, 4] Many environmental factors (e.g., birth mode, feeding, antibiotics, and...

Sep 14, 2023 | biorxiv.org | Ole Baek |Tik Muk |Ziyuan Wu |Yongxin Ye

AbstractPreterm infants are susceptible to neonatal sepsis, which may stem from their distinct immune phenotype, high parenteral glucose provision and poor glucose regulatory capacity. Using a preterm pig model of neonatal sepsis, we previously showed that a high glucose supply during infection predisposed to sepsis via exaggerated glycolysis-induced inflammation. Now we explored options of reducing glucose intake to decrease sepsis risk, without causing hypoglycemia.