Jonathan Tan

1 month ago | nature.com | Jinming Cheng |Fusheng Guo |Felicity C. Jackling |Jicheng Yang |Jonathan Tan |Nick Barker | +14 more

Hair follicles cycle through expansion, regression and quiescence. To investigate the role of MCL‑1, a BCL‑2 family protein with anti‑apoptotic and apoptosis‑unrelated functions, we delete Mcl‑1 within the skin epithelium using constitutive and inducible systems. Constitutive Mcl‑1 deletion does not impair hair follicle organogenesis but leads to gradual hair loss and elimination of hair follicle stem cells. Acute Mcl‑1 deletion rapidly depletes activated hair follicle stem cells and completely blocks depilation‑induced hair regeneration in adult mice, while quiescent hair follicle stem cells remain unaffected. Single‑cell RNA‑seq profiling reveals the engagement of P53 and DNA mismatch repair signaling in hair follicle stem cells upon depilation‑induced activation. Trp53 deletion rescues hair regeneration defects caused by acute Mcl‑1 deletion, highlighting a critical interplay between P53 and MCL‑1 in balancing proliferation and death. The ERBB pathway plays a central role in sustaining the survival of adult activated hair follicle stem cells by promoting MCL‑1 protein expression. Remarkably, the loss of a single Bak allele, a pro‑apoptotic Bcl‑2 effector gene, rescues Mcl‑1 deletion‑induced defects in both hair follicles and mammary glands. These findings demonstrate the pivotal role of MCL‑1 in inhibiting proliferation stress‑induced apoptosis when quiescent stem cells activate to fuel tissue regeneration. Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Jan 16, 2025 | paultan.org | Jonathan Tan

Geely has inaugurated a new plant in Egypt’s 6 October City that will produce the Emgrand sedan (on which the Proton S70 is based) and Coolray SUV (on which the Proton X50 is based), Ahram Online reports. Done in collaboration with Auto Mobility (Geely Egypt), the plant is Geely’s first industrial venture in Egypt, Africa and the Middle East.

Jan 16, 2025 | paultan.org | Jonathan Tan

Would you like to see what the recently-launched 2025 Honda Civic FE facelift looks like in the new Canyon River Blue Metallic exterior colour? Here you go. The entrance of this blue (also found on the CR-V) sees the exit of the pre-facelift’s Lunar Silver Metallic, which you could have on any variant except the hybrid.

Jan 16, 2025 | paultan.org | Jonathan Tan

@yaya.tasha Tak tau la nak suka ke duka.. 😂#fyp #fypage #fy #funnymoments ♬ Oh No – Kreepa This is going viral on TikTok, posted by user @yaya.tasha, showing an incredible RM2,084 fee to park her car at Kuala Lumpur International Airport’s (KLIA) Terminal 1 for 13 days and 18 hours. “Tak tau la nak suka ke duka (don’t know if I should laugh or cry),” reads the caption.

Jan 16, 2025 | paultan.org | Jonathan Tan

The 400-km East Coast Rail Link (ECRL) track from Maran, Pahang to Kota Bharu, Kelantan has been completed two and a half months ahead of schedule, Malaysia Rail Link (MRL) CEO Datuk Seri Darwis Abdul Razak has said, according to a Bernama report. The ECRL project in Kelantan, which includes the Kota Bharu station (for passengers only) in Bandar Baru Tunjong and the Pasir Puteh station (for goods and passengers) in Cherang Tuli, is 87.8% complete as of December.