Jonathan Tan

2 weeks ago | straitstimes.com | Jonathan Tan |Neo Xiaobin

Hobbyist Jonathan Tan showcases the beauty of the old-school stools and tables in the void decks of Singapore’s Housing Board buildings. The photo series, Lepak Downstairs, was named after the colloquial term for hanging out at the void deck. The pictures, which were taken in estates from Tampines to Telok Blangah, exude an honest simplicity and an unmistakable sense of nostalgia. To photography enthusiast Jonathan Tan, a void deck is anything but void.

1 month ago | paultan.org | Jonathan Tan

Shell Recharge and Proton New Energy Technology (Pro-Net) have teamed up to allow Proton eMas and smart users to locate and pay for EV charging at Shell Recharge stations nationwide through their Proton eMas and …

Mar 22, 2025 | nature.com | Jinming Cheng |Fusheng Guo |Felicity C. Jackling |Jicheng Yang |Jonathan Tan |Nick Barker | +14 more

Hair follicles cycle through expansion, regression and quiescence. To investigate the role of MCL‑1, a BCL‑2 family protein with anti‑apoptotic and apoptosis‑unrelated functions, we delete Mcl‑1 within the skin epithelium using constitutive and inducible systems. Constitutive Mcl‑1 deletion does not impair hair follicle organogenesis but leads to gradual hair loss and elimination of hair follicle stem cells. Acute Mcl‑1 deletion rapidly depletes activated hair follicle stem cells and completely blocks depilation‑induced hair regeneration in adult mice, while quiescent hair follicle stem cells remain unaffected. Single‑cell RNA‑seq profiling reveals the engagement of P53 and DNA mismatch repair signaling in hair follicle stem cells upon depilation‑induced activation. Trp53 deletion rescues hair regeneration defects caused by acute Mcl‑1 deletion, highlighting a critical interplay between P53 and MCL‑1 in balancing proliferation and death. The ERBB pathway plays a central role in sustaining the survival of adult activated hair follicle stem cells by promoting MCL‑1 protein expression. Remarkably, the loss of a single Bak allele, a pro‑apoptotic Bcl‑2 effector gene, rescues Mcl‑1 deletion‑induced defects in both hair follicles and mammary glands. These findings demonstrate the pivotal role of MCL‑1 in inhibiting proliferation stress‑induced apoptosis when quiescent stem cells activate to fuel tissue regeneration. Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Jan 16, 2025 | paultan.org | Jonathan Tan

Geely has inaugurated a new plant in Egypt’s 6 October City that will produce the Emgrand sedan (on which the Proton S70 is based) and Coolray SUV (on which the Proton X50 is based), Ahram Online reports. Done in collaboration with Auto Mobility (Geely Egypt), the plant is Geely’s first industrial venture in Egypt, Africa and the Middle East.

Jan 16, 2025 | paultan.org | Jonathan Tan

Would you like to see what the recently-launched 2025 Honda Civic FE facelift looks like in the new Canyon River Blue Metallic exterior colour? Here you go. The entrance of this blue (also found on the CR-V) sees the exit of the pre-facelift’s Lunar Silver Metallic, which you could have on any variant except the hybrid.