Ting Dong

Nov 27, 2024 | onlinelibrary.wiley.com | Ting Dong |Juha-Pekka Kallunki |Henrik Nilsson |Ann Vanstraelen

1 INTRODUCTION Human capital is among the most important assets for professional service organizations such as audit firms. Theoretical studies show that audit partnerships should reward more talented partners with a larger ownership stake to achieve a higher return for the firm and prevent talented partners from leaving the firm (Gilson & Mnookin, 1985; Huddart & Liang, 2003).

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Ting Dong

AbstractImmune checkpoint inhibitors targeting programmed cell death 1 (PD-1) or programmed cell death-ligand 1 (PD-L1) have achieved impressive antitumor clinical outcomes. However, the limited response rates suggest the incomplete understanding of PD-L1 regulation. Here, we demonstrate that vacuole protein sorting 11 and 18 (VPS11/18), two key players in vesicular trafficking, positively regulate PD-L1 and confer resistance to immune checkpoint blockade therapy.