Jourdan Ewoldt

Nov 8, 2024 | nature.com | Jourdan Ewoldt |Samuel J DePalma |Maggie E. Jewett |Lihua Lou |Micheal A. McLellan |Jin He | +7 more

AbstractRecent innovations in differentiating cardiomyocytes from human induced pluripotent stem cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently, hiPSC-derived cardiomyocytes (hiPSC-CMs) remain immature, leading many in the field to explore approaches to enhance cell and tissue maturation.

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Jennifer Jacquet

Introduction to Special IssueAQUACULTUREJennifer Jacquet https://orcid.org/0000-0002-3807-8060 and Jeremy Jackson https://orcid.org/0000-0002-6080-2254 Authors Info & AffiliationsScience Advances16 Oct 2024Vol 10, Issue 42CREDIT: ArtistGNDphotography / iStockAround the world, the rapid expansion and growth in aquaculture—the farming of aquatic animals and plants—is underway. The scientific conversation has had difficulty keeping pace with the growth of the industry.

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Brent Doiron

AbstractA core problem in systems and circuits neuroscience is deciphering the origin of shared dynamics in neuronal activity: Do they emerge through local network interactions, or are they inherited from external sources? We explore this question with large-scale networks of spatially ordered spiking neuron models where a downstream network receives input from an upstream sender network.

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Yu Deng

Abstractc-di-GAMP was first identified in bacteria to promote colonization, while mammalian 2′3′-cGAMP is synthesized by cGAS to activate STING for innate immune stimulation. However, 2′3′-cGAMP function beyond innate immunity remains elusive. Here, we report that 2′3′-cGAMP promotes cell migration independent of innate immunity. 2′3′-cGAMP interactome analysis identifies the small GTPase Rab18 as a 2′3′-cGAMP binding partner and effector in cell migration control.

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Ting Dong

AbstractImmune checkpoint inhibitors targeting programmed cell death 1 (PD-1) or programmed cell death-ligand 1 (PD-L1) have achieved impressive antitumor clinical outcomes. However, the limited response rates suggest the incomplete understanding of PD-L1 regulation. Here, we demonstrate that vacuole protein sorting 11 and 18 (VPS11/18), two key players in vesicular trafficking, positively regulate PD-L1 and confer resistance to immune checkpoint blockade therapy.