Ting Ni

Bethesda

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Articles

Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers - Nature Communications

Jan 15, 2025 | nature.com | Xudong Zou |Zeyang Wang |Gong-Hong Wei |Wei Li |Ting Ni

AbstractAlthough rare non-coding variants (RVs) play crucial roles in complex traits and diseases, understanding their mechanisms and identifying disease-associated RVs continue to be major challenges. Here we constructed a comprehensive atlas of alternative polyadenylation (APA) outliers (aOutliers), including 1334 3′ UTR and 200 intronic aOutliers, from 15,201 samples across 49 human tissues.
A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study - Nature Communications

Feb 26, 2024 | nature.com | Zeyang Wang |Lihai Gong |Qixuan Wang |Xudong Zou |Mireya Plass |Ting Ni | +3 more

AbstractAlternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying putative cancer susceptibility genes.

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