Tobias Weiss

Dec 9, 2024 | nature.com | Ahmad Ozair |Nicholas Mikolajewicz |Stuart A Grossman |Arjun Sahgal |Emilie Le Rhun |Michael Weller | +12 more

AbstractLeptomeningeal metastatic disease (LMD), encompassing entities of ‘meningeal carcinomatosis’, neoplastic meningitis’ and ‘leukaemic/lymphomatous meningitis’, arises secondary to the metastatic dissemination of cancer cells from extracranial and certain intracranial malignancies into the leptomeninges and cerebrospinal fluid.

Nov 8, 2024 | nature.com | Tomas Martins |Deniz Kaymak |Nazanin Tatari |Sabrina Hogan |Marie-Françoise Ritz |Ewelina M. Bartoszek | +9 more

AbstractA significant challenge for chimeric antigen receptor (CAR) T cell therapy against glioblastoma (GBM) is its immunosuppressive microenvironment, which is densely populated by protumoral glioma-associated microglia and macrophages (GAMs). Myeloid immune checkpoint therapy targeting the CD47-signal regulatory protein alpha (SIRPα) axis induces GAM phagocytic function, but CD47 blockade monotherapy is associated with toxicity and low bioavailability in solid tumors.

Sep 15, 2024 | dailyreporter.esmo.org | Tobias Weiss

Immunotherapy of brain tumours remains a promising treatment strategy given the limited efficacy of current treatments for these tumours and the groundbreaking success of immunotherapy for extracranial malignancies. However, clinical trials of immunotherapy for the treatment of primary brain tumours, predominantly glioma, have not yet conferred a survival benefit compared with conventional cancer treatments.

Oct 16, 2023 | frontiersin.org | Dalian Maritime |Kai Ding |Tobias Weiss |Dennis Larsson

1 IntroductionEndometrial cancer, which originates from the endometrial epithelium, is the sixth most common cancer among women worldwide and is associated with increasing mortality rates. In 2020 alone, there were over 417,000 new cases reported, resulting in 97,000 deaths (1, 2). Consequently, this cancer poses a significant threat to women’s health, particularly in developing countries (3, 4).