Tomasz Szczepański

Aug 27, 2024 | nature.com | Agata Pastorczak |Zuzanna Urbanska |Borys Styka |Zuzanna Nowicka |Tomasz Szczepanski |Tomasz Szczepański | +4 more

AbstractChromothripsis (cth) is a form of genomic instability leading to massive de novo structural chromosome rearrangements in a one-time catastrophic event. It can cause cancer-promoting alterations, such as loss of sequences for tumor-suppressor genes, formation of oncogenic fusions, and oncogene amplifications. We investigated the genetic background and clinical significance of cth in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients.