Tomasz Szczepanski

Aug 27, 2024 | nature.com | Agata Pastorczak |Zuzanna Urbanska |Borys Styka |Zuzanna Nowicka |Tomasz Szczepanski |Tomasz Szczepański | +4 more

AbstractChromothripsis (cth) is a form of genomic instability leading to massive de novo structural chromosome rearrangements in a one-time catastrophic event. It can cause cancer-promoting alterations, such as loss of sequences for tumor-suppressor genes, formation of oncogenic fusions, and oncogene amplifications. We investigated the genetic background and clinical significance of cth in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients.

Nov 2, 2023 | frontiersin.org | Guangzhou Women |Tomasz Szczepanski |Adolfo Martinez |Zhenhua Chen

IntroductionAcute lymphoblastic leukemia (ALL) is a malignant tumor with the highest morbidity, accounting for approximately 25% of cancer diagnoses in children under the age of 15 years (1). With therapeutics’ development, pediatric ALL’s long-term survival rate has reached more than 90%. However, nearly 10%–20% of ALL children relapse after initial complete remission. The mechanism of relapse susceptibility of pediatric ALL is still undiscovered.