Tori Anglin-Foote

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Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men - Nature Communications

1 week ago | nature.com | Meghana S. Pagadala |Tori Anglin-Foote |Nai-Chung Chang |Kyung Lee |Tyler M Seibert |Julie Lynch | +1 more

AbstractGiven the various roles of testosterone in men’s health, we conducted a multi-ancestral genetic analysis of total testosterone, free testosterone, SHBG, and hypogonadism in men within the Million Veteran Program (MVP). Here we identified 157 significant testosterone genetic variants, of which 8 have significant ancestry-specific associations. These variants implicate several genes, including SERPINF2, PRPF8, BAIAP2L1, SHBG, PRMT6, and PPIF, related to liver function.

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