Toshiharu Ninomiya

Nov 12, 2024 | nature.com | Yoshihiko Furuta |Masato Akiyama |Mao Shibata |Jun Hata |Chikashi Terao |Yukihide Momozawa | +5 more

AbstractThe genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). The GWAS confirmed three known WML-associated loci (SH3PXD2A, GFAP, and TRIM47).

May 26, 2024 | nature.com | Toshiharu Ninomiya

AbstractWe investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007–2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia.

Jun 1, 2023 | pubmed.ncbi.nlm.nih.gov | Jun Hata |Toshiharu Ninomiya

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Feb 3, 2023 | nature.com | Masato Akiyama |Saori Sakaue |Kazuyoshi Ishigaki |Makoto Hirata |Koichi Matsuda |Yukihide Momozawa | +4 more

ParticipantsWe used the follow-up data of the BBJ project12. This follow-up survey from 2010 to 2014 included 141,612 participants with 32 systemic diseases at the time of participation13. We included participants genotyped by DNA genotyping array. We excluded individuals <20 years old and participants with amyotrophic lateral sclerosis. After standard quality control of genotype data (described below), we included 137,693 individuals in the analysis.