Toshiyuki Shirai

Aug 29, 2024 | nature.com | Ikuo Otsuka |Toshiyuki Shirai |Xiaoxi Liu |Yoichiro Kamatani |Chikashi Terao

AbstractMosaic chromosomal alterations (mCAs) are classified as mosaic deletions (loss), copy-neutral loss of heterozygosity (CN-LOH), and duplications (gain), attracting special attention as biological aging-related acquired genetic alterations. While these mCAs have been linked with aging and various diseases, no study has investigated their association with suicide risk which is associated with abnormal biological aging.